Search results for "Head and neck neoplasm"

showing 10 items of 184 documents

International validation of the revised European Organisation for Research and treatment of cancer head and neck cancer module, the EORTC QLQ-HN43

2019

Background: We validated the new European Organisation for Research and Treatment of Cancer Quality of Life Head and Neck Module (EORTC QLQ-HN43). Methods: We enrolled 812 patients with head and neck cancer from 18 countries. Group 1 completed the questionnaire before therapy, and 3 and 6 months later. In group 2 (survivors), we determined test–retest reliability using intraclass correlation coefficients (ICC). Internal consistency was assessed using Cronbach's Alpha, the scale structure with confirmatory factor analysis, and discriminant validity with known-group comparisons. Results: Cronbach's alpha was >0.70 in 10 of the 12 multi-item scales. All standardized factor loadings exceeded…

Multimodal therapiesQuality of lifeMalemedicine.medical_specialtySDG 16 - PeacePsychometricsIntraclass correlationMedizinSensitivity and Specificity03 medical and health sciences0302 clinical medicineCronbach's alphaQuality of lifeSurveys and QuestionnairesValidationOutcome Assessment Health CaremedicineHumansProspective Studies030212 general & internal medicineHead and neck cancerReliability (statistics)AgedAged 80 and overbusiness.industryHead and neck cancerSDG 16 - Peace Justice and Strong InstitutionsDiscriminant validityReproducibility of ResultsCancerMiddle Agedmedicine.diseaseCombined Modality Therapy/dk/atira/pure/sustainabledevelopmentgoals/peace_justice_and_strong_institutionsConfirmatory factor analysishumanitiesJustice and Strong Institutions3. Good healthEuropeChemoradiationOtorhinolaryngologyHead and Neck Neoplasms030220 oncology & carcinogenesisQuality of LifePhysical therapyFemalebusinessHead and Neck
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Obstructive Sleep Apnea in Patients with Head and Neck Cancer—More than Just a Comorbidity?

2021

Obstructive sleep apnea is the most common type of sleep-disordered breathing with growing prevalence. Its presence has been associated with poor quality of life and serious comorbidities. There is increasing evidence for coexisting obstructive sleep apnea in patients suffering from head and neck cancer, a condition that ranks among the top ten most common types of cancer worldwide. Routinely, patients with head and neck cancer are treated with surgery, radiation therapy, chemotherapy, immunotherapy or a combination of these, all possibly interfering with the anatomy of the oral cavity, pharynx or larynx. Thus, cancer treatment might worsen already existing obstructive sleep apnea or trigge…

LarynxMedicine (General)Pediatricsmedicine.medical_specialtymedicine.medical_treatmentreviewR5-920Quality of lifemedicineHumansobstructive sleep apneaSleep Apnea Obstructivebusiness.industryPharynxHead and neck cancerCancerGeneral Medicinemedicine.diseaseComorbidityRadiation therapyObstructive sleep apneacomorbiditymedicine.anatomical_structureHead and Neck NeoplasmsQuality of LifeoutcomePharynxhead and neck cancerbusinessMedicina
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Significance of P16INK4A hypermethylation gene in primary head/neck and colorectal tumors: it is a specific tissue event? Results of a 3-year GOIM (G…

2006

Background Methylation of the p16 promoter is one of the most frequent mechanisms of gene inactivation; its incidence is extremely variable according to the type of tumor involved. Our purpose was to analyze the hypermethylation of the p16 promoter in laryngeal squamous cell carcinomas (LSCC), salivary gland (SG) tumors and in colorectal cancer (CRC), to detect any possible association with the clinicopathological features and to determine the prognostic significance of the p16 gene in the tumors analyzed. Patients and methods The hypermethylation of the p16 promoter was prospectively analyzed, by MSP, in a consecutive series of 64 locally advanced LSCC patients, in a consecutive series of …

Oncologymedicine.medical_specialtyColorectal cancerInternal medicinemedicineHumansPromoter Regions GeneticProspective cohort studyNeoplasm StagingUnivariate analysisbusiness.industryGenes p16Incidence (epidemiology)CancerHematologyMethylationDNA Methylationmedicine.diseaseOncologyHead and Neck NeoplasmsSalivary gland cancerDNA methylationCarcinoma Squamous CellColorectal NeoplasmsbusinessP16INK4A head and neck carcinoma
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TLR4 down-regulation identifies high risk HPV infection and integration in head and neck squamous cell carcinomas

2015

TLRs are main actors of the innate immune response against HPV. There are very few studies on the role of TLRs mediated HPV clearance in Head and Neck oncology. Our aim was to evaluate whether TLR4 expression identifies HPV infection and/or HR-HPV integration status in oral and oropharyngeal cancers. By immunohistochemistry we assessed TLR4 levels in OSCC/OPSCC. To detect viral integration or episomic status In situ hybridization for HPV-DNA and Pyro-sequencing techniques have been performed. The relationship between TLR4 expression with HPV infection status has been investigated. ISH HPV positive samples have reported lower levels of TLR4 intensity than negative samples (p = .002). There w…

Oncology0301 basic medicineAdultMalemedicine.medical_specialtyVirus IntegrationCellDown-RegulationIn situ hybridizationBiologyAlphapapillomavirusGeneral Biochemistry Genetics and Molecular Biology03 medical and health sciencesRetrospective StudieInternal medicineCarcinomamedicineHumansVirus IntegrationIn Situ HybridizationRetrospective StudiesAgedAged 80 and overInnate immune systemGeneral Immunology and MicrobiologyHead and Neck NeoplasmAlphapapillomaviruExpression indexHPV infectionvirus diseasesMiddle Agedmedicine.diseasefemale genital diseases and pregnancy complicationsToll-Like Receptor 4medicine.anatomical_structure030104 developmental biologyHead and Neck NeoplasmsImmunologyDNA ViralCarcinoma Squamous CellImmunohistochemistryFemaleHuman
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Ultrasound hyperthermia induces apoptosis in head and neck squamous cell carcinoma: an in vitro study

2016

Background Hyperthermia is considered an efficient complement in the treatment of head and neck squamous cell carcinoma (HNSCC). Hyperthermia induces cell apoptosis in a temperature- and time-dependent manner. However, the molecular mechanism of hyperthermia remains unclear. The aim of this study was to investigate the mechanism of apoptosis induced by ultrasound hyperthermia in HNSCC cell lines HN-30 and HN-13. Material and Methods We examined the dynamic changes of early apoptosis and secondary necrosis in HN-30 and HN-13 cells treated by hyperthermia at 42°C for 10 min. We further examined mitochondrial membrane potential in vitro by ultrasound hyperthermia for different heating temperat…

HyperthermiaPathologymedicine.medical_specialtyNecrosisUltrasonic TherapyApoptosis030218 nuclear medicine & medical imaging03 medical and health sciences0302 clinical medicineTumor Cells CulturedmedicineCarcinomaHumansGeneral DentistryOral Medicine and PathologySquamous Cell Carcinoma of Head and NeckChemistrybusiness.industryResearchUltrasoundHyperthermia Induced:CIENCIAS MÉDICAS [UNESCO]medicine.diseaseHead and neck squamous-cell carcinomaIn vitroOtorhinolaryngologyHead and Neck NeoplasmsApoptosisCell culture030220 oncology & carcinogenesisUNESCO::CIENCIAS MÉDICASCarcinoma Squamous CellCancer researchSurgerymedicine.symptombusinessMedicina Oral Patología Oral y Cirugia Bucal
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Utility of imaging techniques in the diagnosis of oral cancer.

2015

Abstract Purpose Imaging techniques such as magnetic resonance imaging (MRI), computed tomography (CT), and positron emission tomography (PET) are often used to complement the clinical exploration and staging of oral squamous cell carcinoma (OSCC). Which of these techniques is best in establishing correct staging and treatment planning is not clear, however. This study aims to determine which technique is most appropriate for diagnosing the primary tumor and for detecting bone invasion and neck metastases. Material and methods A Medline literature search was made over the last 10 years. In each selected study, we recorded the sample size and sensitivity, specificity and precision. Strengths…

Pathologymedicine.medical_specialtyFuture studiesComputed tomographyPositron Emission Tomography Computed TomographymedicineHumansBasal cellNeoplasm InvasivenessRadiation treatment planningEarly Detection of CancerNeoplasm Stagingmedicine.diagnostic_testbusiness.industryCancerMagnetic resonance imagingmedicine.diseasePrimary tumorMagnetic Resonance ImagingOtorhinolaryngologyPositron emission tomographyHead and Neck NeoplasmsPositron-Emission TomographyCarcinoma Squamous CellSurgeryMouth NeoplasmsRadiologyOral SurgerybusinessTomography X-Ray ComputedJournal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
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DRH1 - a novel blood-based HPV tumour marker.

2020

Abstract Background To date, no studies have successfully shown that a highly specific, blood-based tumour marker to detect clinically relevant HPV-induced disease could be used for screening, monitoring therapy response or early detection of recurrence. This study aims to assess the clinical performance of a newly developed HPV16-L1 DRH1 epitope-specific serological assay. Methods In a multi-centre study sera of 1486 patients (301 Head and Neck Squamous Cell Carcinoma (HNSCC) patients, 12 HIV+ anal cancer patients, 80 HIV-positive patients, 29 Gardasil-9-vaccinees, 1064 healthy controls) were tested for human HPV16-L1 DRH1 antibodies. Analytical specificity was determined using WHO referen…

0301 basic medicineMaleResearch paperlcsh:MedicineHIV InfectionsDiseaseGastroenterologyHNSCC0302 clinical medicineNeoplasmsTumour markerMedicineProspective StudiesAged 80 and overlcsh:R5-920Human papillomavirus 16medicine.diagnostic_testbiologyGeneral MedicineMiddle AgedAnus NeoplasmsVaccinationHead and Neck Neoplasms030220 oncology & carcinogenesisArea Under CurveCarcinoma Squamous CellScreeningBiomarker (medicine)FemaleAntibodylcsh:Medicine (General)Blood testAdultHPV16medicine.medical_specialtyEarly detectionSensitivity and SpecificityGeneral Biochemistry Genetics and Molecular BiologyAntibodies03 medical and health sciencesInternal medicineBiomarkers TumorBlood testAnal cancerHumansPapillomavirus VaccinesAgedbusiness.industrylcsh:RPapillomavirus InfectionsOncogene Proteins Viralmedicine.diseaseHead and neck squamous-cell carcinoma030104 developmental biologyCross-Sectional StudiesCase-Control Studiesbiology.proteinCapsid ProteinsbusinessCarrier ProteinsEBioMedicine
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Melatonin Targets Metabolism in Head and Neck Cancer Cells by Regulating Mitochondrial Structure and Function.

2021

This study was funded by grants from the Ministerio de Economia, Industria y Competitividad y por el Fondo de Desarrollo Regional FEDER, Spain nº SAF2013-49019, SAF2017-85903-P, and from the Consejería de Innovación, Ciencia y Empresa, Junta de Andalucía (P07- CTS- 03135, P10- CTS- 5784, and CTS- 101), Spain. J.F. and L.M. have FPU fellowships from the Ministerio de Educación Cultura y Deporte, Spain. C.R.S. was a schorlarship holder from the Plan Propio de Investigación of the University of Granada.

0301 basic medicine:Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Biochemical Processes::Phosphorylation::Oxidative Phosphorylation [Medical Subject Headings]PhysiologyClinical BiochemistrymelatoninMitochondrionBiochemistryMelatonina:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]0302 clinical medicine:Anatomy::Cells::Cells Cultured::Cell Line [Medical Subject Headings]head and neck cancer cells:Phenomena and Processes::Physiological Phenomena::Pharmacological Phenomena::Drug Resistance::Drug Resistance Neoplasm [Medical Subject Headings]MitophagyMitocondriasChemistryapoptosisglycolysisOXPHOSmitochondria030220 oncology & carcinogenesishormones hormone substitutes and hormone antagonistsmedicine.drug:Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Biochemical Processes::Carbohydrate Metabolism::Glycolysis [Medical Subject Headings]Neoplasias de cabeza y cuello:Diseases::Neoplasms::Neoplasms by Site::Head and Neck Neoplasms [Medical Subject Headings]:Chemicals and Drugs::Inorganic Chemicals::Free Radicals::Reactive Oxygen Species [Medical Subject Headings]Mitofagiafree radicalsOxidative phosphorylationArticleMelatonin03 medical and health sciencesmedicine:Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Growth Processes::Cell Proliferation [Medical Subject Headings]Molecular BiologyRadicales libresCell growth:Chemicals and Drugs::Amino Acids Peptides and Proteins::Proteins::DNA-Binding Proteins::Receptors Cytoplasmic and Nuclear::Receptors Melatonin [Medical Subject Headings]:Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Antineoplastic Agents [Medical Subject Headings]lcsh:RM1-950:Anatomy::Cells::Cellular Structures::Subcellular Fractions::Mitochondria [Medical Subject Headings]Cell Biologymedicine.diseaseHead and neck squamous-cell carcinoma:Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Death::Apoptosis [Medical Subject Headings]Glucólisis030104 developmental biologylcsh:Therapeutics. PharmacologymitophagyApoptosisCancer cellCancer research:Chemicals and Drugs::Hormones Hormone Substitutes and Hormone Antagonists::Hormones::Melatonin [Medical Subject Headings]
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Oral and oropharyngeal squamous cell carcinoma in young adults: A retrospective study in Granada University Hospital

2017

Background This study aims to evaluate and analyze the clinical features and outcomes of oral and oropharyngeal squamous cell carcinoma (SCC) in patients 45 years were randomly selected from the same database. A retrospective analysis was conducted to determine specific features including sites of occurrence, risk factors, sex distribution, socio-economic status, T stage at diagnosis, nodal involvement, degree of tumor differentiation, locoregional failure and overall survival at 5 years was. Further, the results of both groups were compared. Results The male-female ratio was 1.2:1 in the group of young adults and 2.03:1 in the group of patients with an age of >45 years. No significant diff…

MaleSurvivalDiseaseHospitals UniversityCavity cancers0302 clinical medicineRisk Factorsrisk factorsIncidence trendsMedicineYoung adultTongue cancerMiddle AgedUniversity hospital:CIENCIAS MÉDICAS [UNESCO]Risk-factorsOropharyngeal NeoplasmsHead and Neck Neoplasms030220 oncology & carcinogenesisUNESCO::CIENCIAS MÉDICASCarcinoma Squamous CellFemaleMouth Neoplasmsyoung adultsAdultmedicine.medical_specialtyMEDLINE03 medical and health sciencesAgeInternal medicineCarcinomaHumansMortalityGeneral DentistrySurvival rateOral and oropharyngeal squamous cell carcinomaRetrospective StudiesOral Medicine and PathologyNeck-cancer incidencebusiness.industrySquamous Cell Carcinoma of Head and NeckResearchPeopleRetrospective cohort study030206 dentistrypoor prognosismedicine.diseaseSurgeryOtorhinolaryngologySpainT-stageSurgerybusinessHeadMedicina Oral, Patología Oral y Cirugía Bucal
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Is immunohistochemistry more sensitive than hematoxylin-eosin staining for identifying perineural or lymphovascular invasion in oral squamous cell ca…

2021

This study aimed to analyze whether immunohistochemistry (IHC) is more sensitive than hematoxylin-eosin (H&E) staining for identifying perineural invasion (PNI) or lymphovascular invasion (LVI) in oral squamous cell carcinoma (OSCC). In this systematic review and meta-analysis (Prospective Register of Systematic Reviews ? CRD 42021256515), data were obtained from six databases (PubMed, Scopus, LILACS, Web of Science, EBSCO, LIVIVO, Embase) and the grey literature. Cross-sectional observational studies of the diagnostic sensitivity of IHC for PNI and LVI were included. Studies were selected in two phases: first collection and reference retrieval. The Quality Assessment of Diagnostic Accuracy…

Staining and LabelingSquamous Cell Carcinoma of Head and NeckneoplasmsImmunohistochemistrystomatitisCross-Sectional StudiesOtorhinolaryngologyHead and Neck NeoplasmsLymphatic MetastasisCarcinoma Squamous Cellantineoplastic agentsmicrobiotaEosine Yellowish-(YS)HumansMouth NeoplasmsNeoplasm InvasivenessSurgeryimmunotherapyHematoxylinGeneral DentistryUNESCO:CIENCIAS MÉDICASMedicina Oral Patología Oral y Cirugia Bucal
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